src: i.ytimg.com
T-box refers to a group of transcription factors involved in limb and heart development.
In humans and some other animals, defects in the TBX5 gene expression can lead to finger-like thumbs and ventricular septal defects in which there is no separation between the left and right ventricle of the heart and are responsible for Holt-Oram syndrome.
TBX3 is associated with ulnar-mammary syndrome in humans, but is also responsible for the presence or absence of dun color in horses, and has no deleterious effects whether expressed or not.
Genes encoding T-box proteins include:
Video T-box
See also
- Brachyury, the first found
- Homeobox
- Development genes in plants: G-box, I-box, W-box, Z-box
Maps T-box
References
src: i.ytimg.com
Further reading
- Meisler (1997). "Mutation watch: Mouse brachyury (T), the T-box gene family, and human disease".
src: i.ytimg.com
External links
- T-Box Domain Proteins at the US National Library of Medicine Medical Subject Headings (MeSH)
Source of the article : Wikipedia
0 Comments